I havnt actually tried this but I wouldnt think so. But I can tell you that running two instances of SQL R2 Standard on the same box as Server Enterprise with 8 sockets (4 cores on each) and splitting cores over the two instances (16 each) as well at the server RAM 64 gig on each instance, works a treat. We also have this clustered to a VM farm (passive) and again, it works brilliantly. Its quite a nifty way of getting round buying an Enterprise Licence